[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$fBdX61djBQZkMuGa1f8hgl2_KzfuHK5P4VcQkZ-bdOw8":3},{"item":4,"storyV2":71},{"slug":5,"type":6,"track":7,"season":8,"date":9,"featured":10,"teamName":11,"institution":13,"projectTitle":15,"summary":18,"body":20,"tags":24,"aiTags":27,"wetlabTags":30,"awards":33,"logoUrl":36,"materials":37,"gallery":38,"editorial":46,"cover":69},"qiushi","image","T1","2026","2026-01-01",false,{"zh":12,"en":12},"求是大队",{"zh":14,"en":14},"天津大学合成生物与生物制造学院",{"zh":16,"en":17},"Genome-to-RNA —— 自动靶点发现与 siRNA 设计","Genome-to-RNA — automated target discovery and siRNA design",{"zh":19,"en":19},"人工智能驱动烟曲霉基因组靶点发现与精准抗真菌 siRNA 药物设计",{"zh":21,"en":23},[22],"烟曲霉位列 WHO 真菌优先级清单首位，耐药性问题严峻。天津大学「求是大队」想用 AI 从它的基因组里自动找出全新靶点、设计 siRNA。",[22],{"zh":25,"en":26},[],[],{"zh":28,"en":29},[],[],{"zh":31,"en":32},[],[],{"zh":34,"en":35},[],[],"\u002Fapi\u002Fteam-showcase\u002Fqiushi\u002Fmedia\u002Fc1239827e5140e4b0be152fcc",{},[39],{"imageUrl":40,"alt":41,"title":43,"description":44,"position":45},"\u002Fapi\u002Fteam-showcase\u002Fqiushi\u002Fmedia\u002Fce093b5a79c0ab9e9a34bd162",{"zh":42,"en":42},"求是大队项目方法与证据图",{"zh":42,"en":42},{"zh":42,"en":42},"center center",{"proposition":47,"listEvidence":48},{"zh":19,"en":19},[49,54,59,64],{"value":50,"label":52},{"zh":51,"en":51},"6 人",{"zh":53,"en":53},"成员人数",{"value":55,"label":57},{"zh":56,"en":56},"陈禹孛",{"zh":58,"en":58},"队长",{"value":60,"label":62},{"zh":61,"en":61},"烟曲霉siRNA",{"zh":63,"en":63},"项目对象",{"value":65,"label":67},{"zh":66,"en":66},"无细胞与酵母",{"zh":68,"en":68},"验证方式",{"tone":70,"heroImageUrl":40,"heroImagePosition":45},"bio",{"version":72,"publicSlug":5,"identity":73,"proposition":77,"lead":78,"listEvidence":79,"narrativeTendency":92,"hero":93,"presentation":96,"chapters":107},2,{"teamName":74,"projectTitle":75,"institution":76,"track":7},{"zh":12,"en":12},{"zh":16,"en":17},{"zh":14,"en":14},{"zh":19,"en":19},{"zh":22,"en":22},[80,83,86,89],{"value":81,"label":82},{"zh":51,"en":51},{"zh":53,"en":53},{"value":84,"label":85},{"zh":56,"en":56},{"zh":58,"en":58},{"value":87,"label":88},{"zh":61,"en":61},{"zh":63,"en":63},{"value":90,"label":91},{"zh":66,"en":66},{"zh":68,"en":68},"evidence-led",{"role":94,"alt":95,"position":45,"imageUrl":40},"TEAM",{"zh":42,"en":42},{"template":97,"variant":98,"logo":99,"openingMedia":106},"documentary-profile","rich",{"role":100,"title":101,"caption":103,"alt":105,"position":45,"imageUrl":36},"LOGO",{"zh":102,"en":102},"求是大队队徽",{"zh":104,"en":104},"队徽：一个空的矩形框，下面写着「求是大队 | Seek Veritas · Tianjin University」。",{"zh":104,"en":104},[],[108,119,128,162,188,208,241],{"id":109,"eyebrow":110,"title":112,"theme":114,"type":115,"quote":116,"attribution":118},"team-motto",{"zh":111,"en":111},"队伍口号",{"zh":113,"en":113},"队伍声音","people","quote",{"zh":117,"en":117},"求是大队 · Seek Veritas",{"zh":12,"en":12},{"id":120,"eyebrow":121,"title":123,"body":125,"theme":127,"type":127},"project-background",{"zh":122,"en":122},"项目背景",{"zh":124,"en":124},"一个排在 WHO 清单首位的真菌",{"zh":126,"en":126},"烟曲霉（*Aspergillus fumigatus*）—— 它位列 WHO 真菌优先级清单首位。这是一种机会性致病菌，每年在世界范围内引起的感染与死亡病例都很多；现有抗真菌药种类有限，并面临疗效与副作用方面的限制。更棘手的是耐药性，加上传统药物靶点匮乏、研发周期长。","problem",{"id":129,"eyebrow":130,"title":132,"body":134,"theme":136,"type":137,"facts":138,"image":154},"research-context",{"zh":131,"en":131},"研究路径",{"zh":133,"en":133},"Genome-to-RNA：从基因组直接推到药",{"zh":135,"en":135},"系统按基因必需性、物种特异性和 mRNA 可及性筛选靶点，并生成以高特异性、低脱靶风险为设计目标的候选 siRNA。候选仍需在无细胞体系和替身模型中验证。","source","source-context",[139,144,149],{"label":140,"value":142},{"zh":141,"en":141},"病原",{"zh":143,"en":143},"烟曲霉",{"label":145,"value":147},{"zh":146,"en":146},"验证",{"zh":148,"en":148},"无细胞体系 + 酵母替身",{"label":150,"value":152},{"zh":151,"en":151},"生物安全",{"zh":153,"en":153},"RG1、BSL-1",{"role":155,"title":156,"caption":158,"alt":160,"position":45,"imageUrl":161},"RESULT",{"zh":157,"en":157},"技术路线图",{"zh":159,"en":159},"Genome-to-RNA —— 从基因组输入，到靶点发现、siRNA 设计，再到无细胞与酵母双轨验证，最后数据回流。",{"zh":159,"en":159},"\u002Fapi\u002Fteam-showcase\u002Fqiushi\u002Fmedia\u002Fc16abb2e8e4a33cea4f9e91a6",{"id":163,"eyebrow":164,"title":166,"theme":168,"type":169,"semantics":170,"steps":171},"project-process",{"zh":165,"en":165},"项目过程",{"zh":167,"en":167},"项目推进与验证路径","process","process-flow","hybrid",[172,181],{"order":173,"phase":174,"title":176,"body":178,"status":180},1,{"zh":175,"en":175},"阶段 1",{"zh":177,"en":177},"RG1、BSL-1 条件下的安全双轨验证",{"zh":179,"en":179},"项目不开展烟曲霉活体操作，采用无细胞 mRNA 切割体系与酿酒酵母替身模型双轨验证，在 RG1、BSL-1 条件下复核 siRNA 预测结果。","described",{"order":72,"phase":182,"title":184,"body":186,"status":180},{"zh":183,"en":183},"阶段 2",{"zh":185,"en":185},"底盘模型的安全性重选",{"zh":187,"en":187},"最初方案直接使用烟曲霉，但实验室条件无法支撑相应操作。团队按安全性与遗传操作可行性重新筛选，改用酿酒酵母作为替身模型。",{"id":189,"eyebrow":190,"title":192,"theme":194,"type":195,"items":196},"project-figure",{"zh":191,"en":191},"项目证据",{"zh":193,"en":193},"项目图表与方法记录","evidence","figures",[197,204],{"role":155,"title":198,"caption":200,"alt":202,"position":45,"imageUrl":203},{"zh":199,"en":199},"项目海报",{"zh":201,"en":201},"AI 驱动的靶点发现与小 RNA 药物设计。",{"zh":201,"en":201},"\u002Fapi\u002Fteam-showcase\u002Fqiushi\u002Fmedia\u002Fca4d834fc5ccdb789c4231b68",{"role":205,"alt":206,"position":45,"imageUrl":207},"METHOD",{"zh":42,"en":42},"\u002Fapi\u002Fteam-showcase\u002Fqiushi\u002Fmedia\u002Fc0add33188ae0077f0368b388",{"id":209,"eyebrow":210,"title":212,"theme":114,"type":214,"items":215},"team-gallery",{"zh":211,"en":211},"团队协作",{"zh":213,"en":213},"计算、实验与候选复核记录","gallery",[216,223,226,229,232,235,238],{"role":94,"title":217,"caption":219,"alt":221,"position":45,"imageUrl":222},{"zh":218,"en":218},"核心成员介绍",{"zh":220,"en":220},"成员介绍拼版列出六名核心成员的姓名与照片，用于呈现团队构成。",{"zh":220,"en":220},"\u002Fapi\u002Fteam-showcase\u002Fqiushi\u002Fmedia\u002Fc1175c8a1d6a0f4d321116b8c",{"role":205,"alt":224,"position":45,"imageUrl":225},{"zh":42,"en":42},"\u002Fapi\u002Fteam-showcase\u002Fqiushi\u002Fmedia\u002Fc5a4b069fb36348775755032c",{"role":205,"alt":227,"position":45,"imageUrl":228},{"zh":42,"en":42},"\u002Fapi\u002Fteam-showcase\u002Fqiushi\u002Fmedia\u002Fc35af1aa0d977caad27b426d3",{"role":205,"alt":230,"position":45,"imageUrl":231},{"zh":42,"en":42},"\u002Fapi\u002Fteam-showcase\u002Fqiushi\u002Fmedia\u002Fcdc503febf3a367a5d0a64e54",{"role":205,"alt":233,"position":45,"imageUrl":234},{"zh":42,"en":42},"\u002Fapi\u002Fteam-showcase\u002Fqiushi\u002Fmedia\u002Fc0231efccddc94a634998de97",{"role":205,"alt":236,"position":45,"imageUrl":237},{"zh":42,"en":42},"\u002Fapi\u002Fteam-showcase\u002Fqiushi\u002Fmedia\u002Fcdcddf0fbacf044116680a395",{"role":205,"alt":239,"position":45,"imageUrl":240},{"zh":42,"en":42},"\u002Fapi\u002Fteam-showcase\u002Fqiushi\u002Fmedia\u002Fc26c016027dbfd323347b3383",{"id":242,"eyebrow":243,"title":245,"theme":247,"type":248,"highlight":249,"full":258},"team-interview",{"zh":244,"en":244},"队伍专访",{"zh":246,"en":246},"听 求是大队 讲述项目路径","media","interview",{"version":250,"title":251,"description":253,"durationSeconds":255,"videoUrl":256,"posterUrl":257},"highlight",{"zh":252,"en":252},"项目精华",{"zh":254,"en":254},"项目核心内容与队伍表达的精华剪辑。",146.000167,"\u002Fapi\u002Fteam-showcase\u002Fqiushi\u002Fmedia\u002Fca6c1011f8e9e0a23f76bbeeb","\u002Fapi\u002Fteam-showcase\u002Fqiushi\u002Fmedia\u002Fcbdff61661f2ae18593075835",{"version":259,"title":260,"description":262,"durationSeconds":264,"videoUrl":265,"posterUrl":257},"full",{"zh":261,"en":261},"完整访谈",{"zh":263,"en":263},"按采访问题完整收录的队伍访谈。",355.8,"\u002Fapi\u002Fteam-showcase\u002Fqiushi\u002Fmedia\u002Fc4764ad73448aabded383994e"]