[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$fpfvoY35VlOWTym36LjjmMNjpFFkZP40Wrf5HTCkF_Vc":3},{"item":4,"storyV2":73},{"slug":5,"type":6,"track":7,"season":8,"date":9,"featured":10,"teamName":11,"institution":13,"projectTitle":15,"summary":18,"body":20,"tags":24,"aiTags":27,"wetlabTags":30,"awards":33,"logoUrl":36,"materials":37,"gallery":38,"editorial":47,"cover":70},"peptide-screen","image","T1","2026","2026-01-01",false,{"zh":12,"en":12},"肽会筛了",{"zh":14,"en":14},"清华大学药学院",{"zh":16,"en":17},"SGLT2 短肽抑制剂 —— 生成模型与干湿闭环筛选","SGLT2 peptide inhibitors — generative dry-wet closed-loop screening",{"zh":19,"en":19},"AI 生成设计 + 结构预测筛选 + 1-NBDG 细胞功能实验，找靶向 SGLT2 的短肽抑制剂",{"zh":21,"en":23},[22],"清华大学「肽会筛了」要找的是能抑制 SGLT2 的短肽 —— 一种在糖尿病治疗中早已验证、但现有药物几乎全是小分子的靶点。",[22],{"zh":25,"en":26},[],[],{"zh":28,"en":29},[],[],{"zh":31,"en":32},[],[],{"zh":34,"en":35},[],[],"\u002Fapi\u002Fteam-showcase\u002Fpeptide-screen\u002Fmedia\u002Fc5bc758d6f93f1b14f90c656e",{},[39],{"imageUrl":40,"alt":41,"title":43,"description":45,"position":46},"\u002Fapi\u002Fteam-showcase\u002Fpeptide-screen\u002Fmedia\u002Fc493c2612ac2d7a5664165e3f",{"zh":42,"en":42},"成员在双屏工作位整理候选信息，对接模型筛选与实验端的数据需求。",{"zh":44,"en":44},"计算端工作记录",{"zh":42,"en":42},"center center",{"proposition":48,"listEvidence":49},{"zh":19,"en":19},[50,55,60,65],{"value":51,"label":53},{"zh":52,"en":52},"4 人",{"zh":54,"en":54},"成员人数",{"value":56,"label":58},{"zh":57,"en":57},"王艺霖",{"zh":59,"en":59},"队长",{"value":61,"label":63},{"zh":62,"en":62},"SGLT2",{"zh":64,"en":64},"项目靶点",{"value":66,"label":68},{"zh":67,"en":67},"1-NBDG 细胞摄取",{"zh":69,"en":69},"验证方式",{"tone":71,"heroImageUrl":72,"heroImagePosition":46},"bio","\u002Fapi\u002Fteam-showcase\u002Fpeptide-screen\u002Fmedia\u002Fccad717d5ce7ffe4ad08afc5f",{"version":74,"publicSlug":5,"identity":75,"proposition":79,"lead":80,"listEvidence":81,"narrativeTendency":94,"hero":95,"presentation":100,"chapters":111},2,{"teamName":76,"projectTitle":77,"institution":78,"track":7},{"zh":12,"en":12},{"zh":16,"en":17},{"zh":14,"en":14},{"zh":19,"en":19},{"zh":22,"en":22},[82,85,88,91],{"value":83,"label":84},{"zh":52,"en":52},{"zh":54,"en":54},{"value":86,"label":87},{"zh":57,"en":57},{"zh":59,"en":59},{"value":89,"label":90},{"zh":62,"en":62},{"zh":64,"en":64},{"value":92,"label":93},{"zh":67,"en":67},{"zh":69,"en":69},"evidence-led",{"role":96,"title":97,"caption":98,"alt":99,"position":46,"imageUrl":40},"TEAM",{"zh":44,"en":44},{"zh":42,"en":42},{"zh":42,"en":42},{"template":101,"variant":102,"logo":103,"openingMedia":110},"documentary-profile","rich",{"role":104,"title":105,"caption":107,"alt":109,"position":46,"imageUrl":36},"LOGO",{"zh":106,"en":106},"肽会筛了队徽",{"zh":108,"en":108},"队徽：一圈由 DNA 与电路走线合成的环，圈住中间那段短肽。",{"zh":108,"en":108},[],[112,123,132,166,206,246],{"id":113,"eyebrow":114,"title":116,"theme":118,"type":119,"quote":120,"attribution":122},"team-motto",{"zh":115,"en":115},"队伍口号",{"zh":117,"en":117},"队伍声音","people","quote",{"zh":121,"en":121},"以 AI 寻肽，以实验证真",{"zh":12,"en":12},{"id":124,"eyebrow":125,"title":127,"body":129,"theme":131,"type":131},"project-background",{"zh":126,"en":126},"项目背景",{"zh":128,"en":128},"一个被验证过的靶点，和一种没被用过的形态",{"zh":130,"en":130},"人体肾脏里有一种叫 SGLT2 的「葡萄糖回收通道」，会把原尿中的葡萄糖重新运回血液。适当抑制它，就能减少葡萄糖的重吸收 —— 这是糖尿病治疗中早已得到验证的机制。现有药物以小分子抑制剂为主；而对形态结构复杂的膜蛋白来说，依赖传统经验和低通量实验的筛选方式周期长、成本高、效率低。所以项目团队同时动了两样东西：药物形态换成短肽，筛选方式换成 AI 生成加实验闭环。短肽的好处是介于小分子与抗体之间 —— 比小分子更容易覆盖大而平坦的结合面，又比抗体更容易合成与递送。代价是序列空间极大，硬搜不现实。","problem",{"id":133,"eyebrow":134,"title":136,"theme":138,"type":139,"semantics":140,"steps":141},"project-process",{"zh":135,"en":135},"项目过程",{"zh":137,"en":137},"项目推进与验证路径","process","process-flow","hybrid",[142,151,158],{"order":143,"phase":144,"title":146,"body":148,"status":150},1,{"zh":145,"en":145},"阶段 1",{"zh":147,"en":147},"对生成模型的一段冷静判断",{"zh":149,"en":149},"团队认为，生成模型降低了候选设计的门槛，但仍需实验筛选。以其采用的流程为例，RFdiffusion 生成主链，ProteinMPNN 再将主链还原为序列；团队指出，序列生成步骤没有直接纳入靶标条件，因此计划把真实活性数据用于约束下一轮候选生成。","described",{"order":74,"phase":152,"title":154,"body":156,"status":150},{"zh":153,"en":153},"阶段 2",{"zh":155,"en":155},"算了一下周期，然后改道",{"zh":157,"en":157},"团队原计划自行表达纯化多肽，但评估周期后判断无法在赛期内完成，于是改用化学合成取得前十条候选肽并进入功能验证。团队将这一调整视为在理想方案与时间约束之间的取舍。",{"order":159,"phase":160,"title":162,"body":164,"status":150},3,{"zh":161,"en":161},"阶段 3",{"zh":163,"en":163},"用 1-NBDG 评估候选肽",{"zh":165,"en":165},"团队用荧光葡萄糖类似物 1-NBDG 观察细胞摄取变化，以评估候选肽对 SGLT2 通道的影响。当前公开结果只说明验证方法和候选范围，不给出阳性率或富集倍数。",{"id":167,"eyebrow":168,"title":170,"theme":172,"type":173,"items":174},"project-figure",{"zh":169,"en":169},"项目证据",{"zh":171,"en":171},"项目图表与方法记录","evidence","figures",[175,183,190,198],{"role":176,"title":177,"caption":179,"alt":181,"position":46,"imageUrl":182},"DRY_LAB",{"zh":178,"en":178},"模型与项目资料整理",{"zh":180,"en":180},"成员在个人工作位整理候选序列、模型结果与实验反馈，准备下一轮筛选。",{"zh":180,"en":180},"\u002Fapi\u002Fteam-showcase\u002Fpeptide-screen\u002Fmedia\u002Fcf02106188ee269416c9fa321",{"role":184,"title":185,"caption":187,"alt":189,"position":46,"imageUrl":72},"WET_LAB",{"zh":186,"en":186},"显微镜下观察细胞",{"zh":188,"en":188},"队员在显微镜前检查细胞状态，为 1-NBDG 摄取实验确认可用的培养条件。",{"zh":188,"en":188},{"role":191,"title":192,"caption":194,"alt":196,"position":46,"imageUrl":197},"EQUIPMENT",{"zh":193,"en":193},"电泳设备准备",{"zh":195,"en":195},"电泳槽、缓冲液与电源记录实验室内的样品分析设备配置。",{"zh":195,"en":195},"\u002Fapi\u002Fteam-showcase\u002Fpeptide-screen\u002Fmedia\u002Fc1eb450195fbc1ed0822a8008",{"role":199,"title":200,"caption":202,"alt":204,"position":46,"imageUrl":205},"RESULT",{"zh":201,"en":201},"离心处理实验样品",{"zh":203,"en":203},"离心设备用于细胞与反应样品处理，为后续荧光摄取读数准备统一样本。",{"zh":203,"en":203},"\u002Fapi\u002Fteam-showcase\u002Fpeptide-screen\u002Fmedia\u002Fcabf235bf9ff3f736dee338d7",{"id":207,"eyebrow":208,"title":210,"theme":118,"type":212,"items":213},"team-gallery",{"zh":209,"en":209},"团队协作",{"zh":211,"en":211},"计算、实验与候选复核记录","gallery",[214,218,225,232,239],{"role":176,"alt":215,"position":46,"imageUrl":217},{"zh":216,"en":216},"团队用于整理项目概况的协作文档界面","\u002Fapi\u002Fteam-showcase\u002Fpeptide-screen\u002Fmedia\u002Fce4f0f320cb08e902642b3b30",{"role":184,"title":219,"caption":221,"alt":223,"position":46,"imageUrl":224},{"zh":220,"en":220},"细胞培养条件维护",{"zh":222,"en":222},"队员操作培养设备，维持候选肽功能验证所需的细胞培养条件。",{"zh":222,"en":222},"\u002Fapi\u002Fteam-showcase\u002Fpeptide-screen\u002Fmedia\u002Fc10b724235b1ac6c11330f9f1",{"role":184,"title":226,"caption":228,"alt":230,"position":46,"imageUrl":231},{"zh":227,"en":227},"1-NBDG 摄取实验",{"zh":229,"en":229},"多孔板承载细胞摄取实验，荧光信号用于评估候选肽对 SGLT2 功能的影响。",{"zh":229,"en":229},"\u002Fapi\u002Fteam-showcase\u002Fpeptide-screen\u002Fmedia\u002Fc47fe5009ee32325d60d02f7b",{"role":184,"title":233,"caption":235,"alt":237,"position":46,"imageUrl":238},{"zh":234,"en":234},"多孔板移液操作",{"zh":236,"en":236},"队员按统一条件向多孔板加样，使不同候选肽的细胞摄取结果具有可比性。",{"zh":236,"en":236},"\u002Fapi\u002Fteam-showcase\u002Fpeptide-screen\u002Fmedia\u002Fc5f5cf9527f7db47dc7cc6ba5",{"role":184,"title":240,"caption":242,"alt":244,"position":46,"imageUrl":245},{"zh":241,"en":241},"细胞实验样品配置",{"zh":243,"en":243},"超净工作台内完成样品分装和多孔板处理，准备比较不同候选肽的功能读出。",{"zh":243,"en":243},"\u002Fapi\u002Fteam-showcase\u002Fpeptide-screen\u002Fmedia\u002Fc56e403ba1df64f9c384b0f2c",{"id":247,"eyebrow":248,"title":250,"theme":252,"type":253,"highlight":254,"full":263},"team-interview",{"zh":249,"en":249},"队伍专访",{"zh":251,"en":251},"听 肽会筛了 讲述项目路径","media","interview",{"version":255,"title":256,"description":258,"durationSeconds":260,"videoUrl":261,"posterUrl":262},"highlight",{"zh":257,"en":257},"项目精华",{"zh":259,"en":259},"项目核心内容与队伍表达的精华剪辑。",120.268,"\u002Fapi\u002Fteam-showcase\u002Fpeptide-screen\u002Fmedia\u002Fc08484efa11cadab50ef73ffc","\u002Fapi\u002Fteam-showcase\u002Fpeptide-screen\u002Fmedia\u002Fc6196305fa3118923c4b1a976",{"version":264,"title":265,"description":267,"durationSeconds":269,"videoUrl":270,"posterUrl":262},"full",{"zh":266,"en":266},"完整访谈",{"zh":268,"en":268},"按采访问题完整收录的队伍访谈。",419.412125,"\u002Fapi\u002Fteam-showcase\u002Fpeptide-screen\u002Fmedia\u002Fca5ae4b82f68dc44cbe75adaf"]